検索結果

Search Results for " colorectal cancer "

ターゲット

138

阻害剤

天然化合物

リコンビナントタンパク質

ライブラリー

カタログ番号	製品名	別名	ターゲット
T9963	MPT0B390		HDAC
	MPT0B390 is an inhibitor of HDAC and a TIMP3 inducer inhibiting tumor growth, metastasis, and angiogenesis.		HDAC
T9202	DDO-5936		HSP
	DDO-5936 is a potent and specific HSP90-Cdc37 PPI inhibitor.		HSP
T9810	TNIK-IN-5		Wnt/beta-catenin
	TNIK-IN-5 is an potent TNIK inhibitor (IC50= 0.05 μM). TNIK-IN-5 potently inhibits Wnt signaling in intact cells. TNIK-IN-5 exhibits excellent in vitro anti-colorectal cancer activity.		Wnt/beta-catenin
T9148	KA2507		HDAC
	KA2507 is a potent and selective HDAC6 inibitor with an IC50 of 2.5nM.		HDAC
T60037	SR15006		DNA/RNA Synthesis
	SR15006 is Krüppel-like factor 5 (KLF5) inhibitor (IC50 = 41.6 nM).		DNA/RNA Synthesis
T4985	Neticonazole Hydrochloride		Antifungal
	Neticonazole Hydrochloride is an imidazole antifungal for the treatment of fungal skin infections. Neticonazole is reported as a potent exosome inhibitor which can block the activity of exosomes.		Antifungal
T1867	Otenaproxesul	ATB 346	Apoptosis , COX
	Otenaproxesul (ATB 346) is a novel hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity.		Apoptosis , COX
T24437	MCP110	MCP-110,MCP 110	Raf , Ras
	MCP110 is an inhibitor of the interaction of Ras with Raf-1 and can be used in studies about the treatment of human tumors.		Raf , Ras
T11285	FIDAS-5		Others
	FIDAS-5, a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM, competitively inhibits S-adenosylmethionine (SAM) binding to MAT2A. It exhibits anticancer activities.		Others
T6275	Obatoclax Mesylate	Obatoclax,GX15-070	BCL , Parasite , Autophagy
	Obatoclax Mesylate (GX15-070) is a Bcl-2 antagonist (Ki: 0.22 μM) and can induce apoptosis with up-regulation of Bim, induced cytochrome c release, and activation of caspase-3.		BCL , Parasite , Autophagy
T8545	FEN1-IN-4	FEN1 Inhibitor C2	Others
	FEN1-IN-4 (FEN1 Inhibitor C2) is an inhibitor of human flap endonuclease-1 (hFEN1)		Others
T22318	Taletrectinib	DS-6051b,AB-106	Trk receptor , ROS , ROS Kinase
	Taletrectinib (AB-106) is a new-generation selective inhibitor of ROS1/NTRK including ROS1,NTRK1,NTRK2 and NTRK3 with IC50 of 0.207 nM,0.622 nM,2.28 nM and 0.980 nM, respectively.		Trk receptor , ROS , ROS Kinase
T2301	SB 202190	FHPI,SB202190	Apoptosis , p38 MAPK , Autophagy
	SB 202190 (FHPI) is a p38 MAPK inhibitor that inhibits p38α and p38β2 (IC50=50/100 nM) selectively and cell-permeably. SB 202190 has antitumor activity and also induces the differentiation of human embryonic stem cells i...		Apoptosis , p38 MAPK , Autophagy
T6255	Bromosporine		Epigenetic Reader Domain , CDK
	Bromosporine is a broad spectrum inhibitor for bromodomains for BRD2/4/9 and CECR2 (IC50: 0.41/0.29/0.122/0.017 μM), respectively.		Epigenetic Reader Domain , CDK
T9696	β-catenin-IN-2		Wnt/beta-catenin
	β-catenin-IN-2 is a potent inhibitor of β-catenin that can be used in colorectal cancer research.		Wnt/beta-catenin
T1290	Oxiconazole nitrate	Ro 13-8996	Others , Antibiotic , Antifection , Antifungal
	Oxiconazole nitrate (Ro 13-8996) is the nitrate salt form of oxiconazole, a broad spectrum imidazole derivative with antifungal activity. Although the exact mechanism of action has yet to be fully elucidated, oxiconazole...		Others , Antibiotic , Antifection , Antifungal
T0459	Sulindac	Arthrocine,MK-231,Clinoril,Sulindac sulfoxide	COX , Autophagy
	Sulindac (Sulindac sulfoxide) is a sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cycl...		COX , Autophagy
T15396	GN44028	N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine	HIF
	GN44028 (N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine) is a hypoxia-inducible factor inhibitor of (HIF)-1 (IC50: 14 nM). GN44028 inhibits hypoxia-induced HIF-1α transcriptional activity. H...		HIF
T2170	SKF-96365 hydrochloride	SKF96365	Apoptosis , Potassium Channel , Calcium Channel , TRP/TRPV Channel , Autophagy
	SKF-96365 hydrochloride (SKF96365) , a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells. SKF-96365 hydrochloride can induce cytoprotective autopha...
T83641	HNPMI		Apoptosis , EGFR
	HNPMI is an EGFR inhibitor that induces G0/G1 phase arrest of CRC cells in colorectal cancer, regulates enzymes associated with apoptosis, may promote apoptosis, and may be used in the study of colorectal cancer.		Apoptosis , EGFR
T6894	ML264	CID-51003603	DNA/RNA Synthesis , KLF
	ML264 (CID-51003603) is a selective kruppel-like factor 5 (KLF5) inhibitor, which potently Inhibits growth of Colorectal Cancer.		DNA/RNA Synthesis , KLF
T27138	Declopramide	OXI-104,IMO-B,3-Chloroprocainamide	Apoptosis
	Declopramide (OXI-104) is a novel chemosensitizer with antitumor activity that induces apoptosis and can be used to study colorectal cancer and inflammatory bowel disease.		Apoptosis
T68051	Delequamine	RS 15385-197	Adrenergic Receptor
	Delequamine (RS 15385-197) is a selective and potent TNIK inhibitor (IC50: 8 nM).TINK-IN-1 inhibits colorectal cancer cell viability and can be used to study mental retardation.		Adrenergic Receptor
T28740	SDZ-62-434	SDZ 62 434,SDZ62434	Platelet aggregation
	SDZ-62-434 is a platelet-activating factor inhibitor with antitumor activity that inhibits bombesin- and platelet-derived growth factor-induced DNA synthesis in quiescent Swiss 3T3 cells for the study of leukemia, human ...		Platelet aggregation
T13810	Palmitoylcarnitine chloride	Palmitoyl DL-carnitine chloride	PKC
	Palmitoylcarnitine chloride (Palmitoyl DL-carnitine chloride) is a mitochondrial fatty acid oxidation intermediate that mediates intralipid cardioprotection.Palmitoylcarnitine chloride eliminates colorectal cancer cell s...		PKC
T76792	Sibrotuzumab	BIBH 1,Anti-Human FAP Recombinant Antibody	Others
	Sibrotuzumab (BIBH 1) is a humanized IgG1 monoclonal antibody targeting Fibroblast Activating Protein (FAP).Sibrotuzumab is used in the study of colorectal cancer and non-small cell lung cancer.		Others
T77407	Ensituximab	NPC-1C,NEO-102,NEO-101
	Ensituximab (NEO-102) is a quasi-selective IgG1 monoclonal antibody against the MUC5AC variant with anti-tumour activity that inhibits colorectal and pancreatic cancer.
TP2320	Pramlintide acetate(151126-32-8 free base)		Others
	Pramlintide acetate is a polypeptide analogue of human amylin. It serves as an antidiabetic agent and exhibits antineoplastic activity in colorectal cancer.		Others
T62061	COX-2-IN-6		COX , Prostaglandin Receptor
	COX-2-IN-6 is a potent, selective, and orally available cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 0.84 μM and a Ki of 69 nM.COX-2-IN-6 inhibits COX-2-driven PGE2 synthesis with an IC50 of 0.60 μM.COX-2-IN-6 is u...		COX , Prostaglandin Receptor
T64066	CSF1R-IN-3		c-Fms , CSF-1R
	CSF1R-IN-3 is an orally effective CSF-1R inhibitor with an IC50 value of 2.1 nM. CSF1R-IN-3 has anti-proliferative activity against colorectal cancer cells. CSF1R-IN-3 exhibits anti-tumour effects and immune enhancing ef...		c-Fms , CSF-1R
T9307	(E)-3-(3,4-dichlorophenyl)-N-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide		Others
	SR18662 a.k.a. SR18662 is a KLF5 inhibitor based on the optimized structure of ML264. It inhibits the growth of colorectal cancer in vitro and in vivo.		Others
T74698	RMC-6236		Ras
	RMC-6236 is a RAS(ON)MULTI inhibitor with anticancer activity and is used in the study of advanced malignant solid tumors and colorectal cancer.		Ras
T9901A-004	Labetuzumab	IMMU-14,hMN-14,IMMU-100
	Labetuzumab is a humanized anti-carcinoembryonic antigen (CEA) monoclonal antibody with anticancer activity that inhibits tumor growth and is used in the study of thyroid and colorectal cancer (CRC).
T22429	SR18662		DNA/RNA Synthesis
	SR18662, an optimized compund based on ML264 that inhibits Krüppel-like factor 5 (KLF5) with IC50 of 4.4 nM, reduces the viability of multiple colorectal cancer cell lines and induces apoptosis.		DNA/RNA Synthesis
T77519	FC-116	FC116	Apoptosis , Microtubule Associated
	FC-116 is a potent Tubulin inhibitor with antitumour activity and inhibits tumour growth in mice. FC-116 induces apoptosis in colorectal cancer (CRC) cells and promotes protein degradation.		Apoptosis , Microtubule Associated
T77660	TINK-IN-1		Wnt/beta-catenin
	TINK-IN-1 is a selective and potent TNIK inhibitor (IC50: 8 nM).TINK-IN-1 inhibits colorectal cancer cell viability and can be used to study mental retardation.		Wnt/beta-catenin
T19802	B-Raf IN 11		Raf
	B-Raf IN 11 is a novel selective inhibitor. The DFG-in conformation of the B-Raf kinase V600E mutant is superior to the DFG-out conformation in colorectal cancer.		Raf
T2618	LGK974	LGK 974,LGK-974,NVP-LGK974,WNT974	Porcupine
	LGK974 (NVP-LGK974) is an effective and selective PORCN inhibitor and inhibits Wnt signaling (IC50: 0.4 nM) in TM3 cells. It has been used in trials studying the treatment of Metastatic Colorectal Cancer and Squamous Cel...		Porcupine
T72068	SFI003		Apoptosis , ROS
	SFI003 is a novel SRSF3 inhibitor that exerts anticancer activity against colorectal cancer by modulating the SRSF3 / DHCR24 / ROS axis and driving apoptosis in CRC cells through the SRSF3 / DHCR24 / reactive oxygen spec...		Apoptosis , ROS
T21567L	Cyclosomatostatin Acetate	Cyclosomatostatin Acetate （84211-54-1 Free base）	Somatostatin
	Cyclosomatostatin Acetate is an effective antagonist of the somatostatin receptor.Cyclosomatostatin Acetate inhibits SSTR1 signaling and decreases cell proliferation, ALDH+ cell population size, and sphere-formation in c...		Somatostatin
T1307	Carmofur	HCFU	Nucleoside Antimetabolite/Analog , Virus Protease , SARS-CoV , DNA/RNA Synthesis
	Carmofur (HCFU) is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencephalopathy.
T24855	TASIN-1 Hydrochloride	TASIN-1 HCl,TASIN 1 HCl,TASIN1 HCl	APC
	TASIN-1 Hydrochloride (TASIN-1 HCl) is a selective inhibitor of truncated APC that acts by selectively killing colorectal cancer cells that express truncated APC by reducing cellular cholesterol levels and inducing apopt...		APC
T9556	TNIK-IN-3		Wnt/beta-catenin
	TNIK-IN-3 is a highly potent and orally active inhibitor of Traf2- and Nck-interacting protein kinase (TNIK). It exhibits a strong selectivity for TNIK with an IC50 value of 0.026 μM. Additionally, TNIK-IN-3 demonstrates...		Wnt/beta-catenin
T77719	TNIK-IN-7		Wnt/beta-catenin
	TNIK-IN-7 is a potent and selective Traf2 and Nck interacting kinase (TNIK) inhibitor (IC50: 11 nM) with antitumor activity for studying signaling and proliferation in colorectal cancer cells.		Wnt/beta-catenin
T76890	Petosemtamab	MCLA 158	EGFR
	Petosemtamab (MCLA 158) is a highly potent monoclonal antibody against EGFR (Kd: 0.22 nM) and LGR5 (Kd: 0.86 nM). Petosemtamab promotes EGFR signaling disruption and receptor breakdown in LGR5+ cancer cells. Petosemtamab...		EGFR
T76674	Cibisatamab		Others
	Cibisatamab is a T-cell bispecific antibody that acts as a T-cell splicer.Cibisatamab targets carcinoembryonic antigen (CEA) on cancer cells and CD3 on T-cells, and triggers T-cell killing when the CEA on the surface of ...		Others
T2283	PX-12	IV-2,PX12	Thioredoxin
	PX-12 (PX12) (1-methylpropyl 2-imidazolyl disulfide) is a small-molecule inhibitor of Trx-1 (thioredoxin-1), stimulates apoptosis, down-regulates HIF-1α and vascular endothelial growth factor (VEGF) and inhibits tumor gr...		Thioredoxin
T9972	Divarasib	GDC-6036	Ras
	Divarasib (GDC-6036) (GDC-6036) is an investigational, oral, high-potency and selective KRAS G12C inhibitor with an IC50 of < 0.01 μM. Divarasib irreversibly locks KRAS G12C oncoprotein in an inactive state and inhibi...		Ras
T4013	SGC2085 HCl		Histone Methyltransferase
	SGC2085 is a potent and selective coactivator associated arginine methyltransferase 1 (CARM1) Inhibitor with an IC50 of 50 nM and more than undred-fold selectivity over other PRMTs. CARM1 is an important positive modulat...		Histone Methyltransferase
T80644	DNA polymerase-IN-1		Antiviral , DNA/RNA Synthesis
	DNA polymerase-IN-1, a DNA polymerase inhibitor, exhibited antiproliferative activity against tumor cells with a half-inhibitory concentration (IC50) of 20.7 μM. DNA polymerase-IN-1 inhibited Taq DNA polymerase with an I...		Antiviral , DNA/RNA Synthesis

Compounds

Target: Wnt/beta-catenin

Target: DNA/RNA Synthesis

Neticonazole Hydrochloride

Target: Apoptosis, COX

MCP110

T24437

Synonym: MCP-110,MCP 110

Synonym: Obatoclax,GX15-070

Target: BCL, Parasite, Autophagy

FEN1-IN-4

T8545

Synonym: FEN1 Inhibitor C2

Target: Others

Taletrectinib

T22318

Synonym: DS-6051b,AB-106

Target: Trk receptor, ROS, ROS Kinase

SB 202190

T2301

Synonym: FHPI,SB202190

Target: Apoptosis, p38 MAPK, Autophagy

Bromosporine

T6255

Synonym:

Target: Epigenetic Reader Domain, CDK

β-catenin-IN-2

T9696

Synonym:

Target: Wnt/beta-catenin

Oxiconazole nitrate

T1290

Synonym: Ro 13-8996

Target: Others, Antibiotic, Antifection, Antifungal

Sulindac

T0459

Synonym: Arthrocine,MK-231,Clinoril,Sulindac sulfoxide

Target: COX, Autophagy

GN44028

T15396

Synonym: N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine

Target: HIF

SKF-96365 hydrochloride

T2170

Synonym: SKF96365

Target: Apoptosis, Potassium Channel, Calcium Channel, TRP/TRPV Channel, Autophagy

HNPMI

T83641

Synonym:

Target: Apoptosis, EGFR

ML264

T6894

Synonym: CID-51003603

Target: DNA/RNA Synthesis, KLF

Declopramide

T27138

Synonym: OXI-104,IMO-B,3-Chloroprocainamide

Target: Apoptosis

Delequamine

T68051

Synonym: RS 15385-197

Target: Adrenergic Receptor

SDZ-62-434

T28740

Synonym: SDZ 62 434,SDZ62434

Target: Platelet aggregation

Palmitoylcarnitine chloride

T13810

Synonym: Palmitoyl DL-carnitine chloride

Target: PKC

Sibrotuzumab

T76792

Synonym: BIBH 1,Anti-Human FAP Recombinant Antibody

Target: Others

Ensituximab

T77407

Synonym: NPC-1C,NEO-102,NEO-101

Target:

Pramlintide acetate(151126-32-8 free base)

Target: COX, Prostaglandin Receptor

CSF1R-IN-3

T64066

Synonym:

Target: c-Fms, CSF-1R

(E)-3-(3,4-dichlorophenyl)-N-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide

Synonym: IMMU-14,hMN-14,IMMU-100

Target: DNA/RNA Synthesis

FC-116

T77519

Synonym: FC116

Target: Apoptosis, Microtubule Associated

TINK-IN-1

T77660

Synonym:

Target: Wnt/beta-catenin

Synonym: LGK 974,LGK-974,NVP-LGK974,WNT974

Target: Apoptosis, ROS

Cyclosomatostatin Acetate

T21567L

Synonym: Cyclosomatostatin Acetate （84211-54-1 Free base）

Target: Nucleoside Antimetabolite/Analog, Virus Protease, SARS-CoV, DNA/RNA Synthesis

TASIN-1 Hydrochloride

T24855

Synonym: TASIN-1 HCl,TASIN 1 HCl,TASIN1 HCl

Target: Wnt/beta-catenin

TNIK-IN-7

T77719

Synonym:

Target: Wnt/beta-catenin

Target: Histone Methyltransferase

DNA polymerase-IN-1

T80644

Synonym:

Target: Antiviral, DNA/RNA Synthesis

カタログ番号	製品名	別名	ターゲット
T3055	Liensinine Perchlorate		Apoptosis , Others
	Liensinine is the active constituent of plumula nelambinis with anti-hypertension.		Apoptosis , Others
TN1465	Cannabigerol		NOS , 5-HT Receptor , ROS
	Cannabigerol is a high affinity α±2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist ; also binds to the CB2 receptor; it can relieve interocular pressur...		NOS , 5-HT Receptor , ROS
T2988	(-)-Epigallocatechin Gallate	Epigallocatechol Gallate,EGCG	Ferroptosis , Reactive Oxygen Species , HIV Protease , Mitochondrial Metabolism , Endogenous Metabolite , Autophagy
	(-)-Epigallocatechin Gallate (EGCG) is an antioxidant polyphenol flavonoid that inhibits telomerase and DNA methyltransferase. (-)-Epigallocatechin Gallate (EGCG) blocks the activation of EGF receptors and HER-2 receptor...
TN1305	Ethoxysanguinarine	6-Ethoxydihydrosanguinarine	Apoptosis , AChR
	Ethoxysanguinarine (6-Ethoxydihydrosanguinarine) shows human blood acetylcholinesterase (HuAChE) and human plasma butyrylcholinesterase (HuBuChE) inhibitory activity, with IC50 values of 0.83 +/- 0.04 microM and 4.20 +/-...		Apoptosis , AChR
T4456	N4-Acetylcytidine	N-Acetylcytidine	Others , Endogenous Metabolite
	N4-Acetylcytidine (N-Acetylcytidine) is a modified nucleoside. N4-acetylcytidine is an endogenous urinary nucleoside product of the degradation of transfer ribonucleic acid (tRNA); urinary nucleosides are biological mark...		Others , Endogenous Metabolite
TQ0193	N2,N2-Dimethylguanosine		Endogenous Metabolite
	N2,N2-Dimethylguanosine is an urinary nucleoside. The mean levels of urinary N2,N2-Dimethylguanosine in patients with colorectal cancer are significantly higher than those in patients with intestinal villous adenoma or h...		Endogenous Metabolite
TJP2872	Acevaltrate	Acevaltratum,Acetoxyvaltrate	ATPase , Others
	1. Acevaltrate (Acevaltratum) displays high cytotoxicity against GLC(4), a human small-cell lung cancer cell line, and against COLO 320, a human colorectal cancer cell line, with IC50 values of 1-6 uM.		ATPase , Others
T8166	Pennogenin 3-O-beta-chacotrioside		Autophagy
	Pennogenin 3-O-beta-chacotrioside is an active component isolated from Paris polyphylla with anti-colorectal cancer activity. It modulates autophagy via increasing the expressions of autophagy-related proteins LC3 and Be...		Autophagy
TN1237	3-O-Methylgallic acid	3,4-Dihydroxy-5-methoxybenzoic acid	Apoptosis , NF-κB , OCT , DNA/RNA Synthesis , STAT
	3-O-Methylgallic acid (3,4-Dihydroxy-5-methoxybenzoic acid) reduces cell proliferation in Caco-2 cells(IC50 = 24.1 μM) more effectively than anthocyanins and may offer protection against colon cancer after its formation ...		Apoptosis , NF-κB , OCT , DNA/RNA Synthesis , STAT
T6599	N6-methyladenosine	N-Methyladenosine,6-Methyladenosine,NSC-29409,m6A	Others , Influenza Virus , Endogenous Metabolite
	N6-methyladenosine (NSC-29409) is a methylated adenine residue. N6-Methyladenosine is an endogenous urinary nucleoside product of the degradation of transfer ribonucleic acid (tRNA); urinary nucleosides are biological ma...		Others , Influenza Virus , Endogenous Metabolite
T36715	Tetrac	Tetraiodothyroacetic acid,3,3',5,5'-Tetraiodothyroacetic acid	Apoptosis , EGFR
	Tetrac (Tetraiodothyroacetic acid) is a derivative of L-thyroxine (T4), a thyroxine integrin receptor antagonist.Tetrac induces antiproliferation by blocking EGFR-mediated cell signaling in colorectal cancer cells.Tetrac...		Apoptosis , EGFR
T2938	(E/Z)-Polydatin	Polydatin,(E/Z)-Piceid	Phospholipase
	(E/Z)-Polydatin (Polydatin), is a natural precursor and glycoside form of resveratrol with a monocrystalline structure. While it is isolated from the bark of Picea sitchensis or Polygonum cuspidatum, Polydatin may be det...		Phospholipase
T8053	N-Acetyl-L-arginine	Ac-Arg-OH	Endogenous Metabolite
	N-Acetyl-L-arginine (Ac-Arg-OH) belongs to the class of organic compounds known as n-acyl-l-alpha-amino acids. These are n-acylated alpha amino acids which have the L-configuration of the alpha-carbon atom. N-a-Acetyl-L-...		Endogenous Metabolite
T3425	Polyphyllin G	Polyphyllin VII,Polyphyllin VII,Y-0166	Others
	Polyphyllin G (Polyphyllin VII), the the main member of polyphyllin family, shows strong anticancer activity against several carcinomas, including lung cancer, breast cancer, colorectal cancer, cervical cancer, hepatocel...		Others
TN3812	Dehydrovomifoliol		AChR
	Dehydrovomifoliol could be a marker of Polish heather honey. Dehydrovomifoliol exhibits moderate acetylcholinesterase (AChE) inhibitory activities. Dehydrovomifoliol shows significant cytotoxic activities against three h...		AChR
T79933	(−)-N-Hydroxyapiosporamide	NHAP	NF-κB
	(−)-N-Hydroxyapiosporamide (NHAP), an alkaloid, serves as an NF-κB inhibitor and demonstrates significant antitumor activity both in vitro and in vivo. It has potential applications in colorectal cancer (CRC) research [1...		NF-κB
TMA0291	Dehydroglyasperin D		GSK-3 , p38 MAPK , ROS , Akt , COX , PI3K , DNA/RNA Synthesis , Prostaglandin Receptor , JNK
	Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 human colorectal cancer cells through direct interaction wit...
T36815	Chevalone C
	Chevalone C is a meroterpenoid fungal metabolite originally isolated from E. chevalieri. It is active against M. tuberculosis H37Ra (MIC = 6.3 μg/ml) and is cytotoxic to BC1 human breast cancer cells (IC50 = 8.7 μg/ml). ...
TN1694	Gliotoxin		Apoptosis , NF-κB , Wnt/beta-catenin , COX , PKA , Antibacterial , Antifection
	Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signaling pathway.

天然物製品

Liensinine Perchlorate

T3055

Synonym:

Target: Apoptosis, Others

Cannabigerol

TN1465

Synonym:

Target: NOS, 5-HT Receptor, ROS

(-)-Epigallocatechin Gallate

T2988

Synonym: Epigallocatechol Gallate,EGCG

Target: Ferroptosis, Reactive Oxygen Species, HIV Protease, Mitochondrial Metabolism, Endogenous Metabolite, Autophagy

Ethoxysanguinarine

TN1305

Synonym: 6-Ethoxydihydrosanguinarine

Target: Apoptosis, AChR

N4-Acetylcytidine

T4456

Synonym: N-Acetylcytidine

Target: Others, Endogenous Metabolite

N2,N2-Dimethylguanosine

TQ0193

Synonym:

Target: Endogenous Metabolite

Acevaltrate

TJP2872

Synonym: Acevaltratum,Acetoxyvaltrate

Target: ATPase, Others

Pennogenin 3-O-beta-chacotrioside

T8166

Synonym:

Target: Autophagy

3-O-Methylgallic acid

TN1237

Synonym: 3,4-Dihydroxy-5-methoxybenzoic acid

Target: Apoptosis, NF-κB, OCT, DNA/RNA Synthesis, STAT

N6-methyladenosine

T6599

Synonym: N-Methyladenosine,6-Methyladenosine,NSC-29409,m6A

Target: Others, Influenza Virus, Endogenous Metabolite

Tetrac

T36715

Synonym: Tetraiodothyroacetic acid,3,3',5,5'-Tetraiodothyroacetic acid

Target: Apoptosis, EGFR

(E/Z)-Polydatin

T2938

Synonym: Polydatin,(E/Z)-Piceid

Target: Phospholipase

N-Acetyl-L-arginine

T8053

Synonym: Ac-Arg-OH

Target: Endogenous Metabolite

Polyphyllin G

T3425

Synonym: Polyphyllin VII,Polyphyllin VII,Y-0166

(−)-N-Hydroxyapiosporamide

Target: GSK-3, p38 MAPK, ROS, Akt, COX, PI3K, DNA/RNA Synthesis, Prostaglandin Receptor, JNK

Target: Apoptosis, NF-κB, Wnt/beta-catenin, COX, PKA, Antibacterial, Antifection

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-04153	RNF43 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	RNF43 mutations are frequently detected in colorectal cancer cells and lead to a loss of function of the ubiquitin E3 ligase. The outer mitochondrial membrane 34 (TOMM34) and ring finger protein 43 (RNF43) as highly expr...
TMPY-00365	GALNT7 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	GalNAc-transferase-7 (GALNT7) is essential for the regulation of cell proliferation and has been implicated in tumorigenesis. Colorectal cancer (CRC) arises in a multistep molecular network process, which is from either ...
TMPY-02292	IGSF11 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Immunoglobulin superfamily member 11(IGSF11) is expressed on the plasma membrane in the testis and brain. These IGSF proteins undergo final modifications during capacitation and/or the acrosome reaction. IGSF proteins sh...
TMPY-02575	PPAR gamma/PPARG Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	Peroxisome proliferator-activated receptor gamma (PPARG), a nuclear hormone receptor, plays a critical role in the lipid and glucose homeostasis, adipocyte differentiation, as well as intracellular insulin-signaling even...
TMPH-02218	JUN Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signali...
TMPH-02219	JUN Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signali...
TMPK-01131	Neogenin Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Neogenin is a multifunctional transmembrane receptor belonging to the immunoglobulin superfamily. It displays identical secondary structure to deleted in colorectal cancer (DCC), a netrin receptor that is involved in axo...
TMPY-04149	RNF43 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	RNF43 mutations are frequently detected in colorectal cancer cells and lead to a loss of function of the ubiquitin E3 ligase. The outer mitochondrial membrane 34 (TOMM34) and ring finger protein 43 (RNF43) as highly expr...
TMPY-02572	TXNDC17 Protein, Human, Recombinant	Human	E. coli
	Thioredoxin-related protein of 14 kDa (TRP14, also called TXNDC17 for thioredoxin domain containing 17, or TXNL5 for thioredoxin-like 5) is an evolutionarily well-conserved member of the thioredoxin (Trx)-fold protein fa...
TMPY-04249	Syndecan-2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	The key players in the miR-20a-5p/SDC2 axis may be a potential diagnostic biomarker and therapeutic target for OS patients. SDC2 methylation as a blood-based DNA test for early detection of colorectal cancer (CRC). Synde...
TMPY-05168	Syndecan-2 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	The key players in the miR-20a-5p/SDC2 axis may be a potential diagnostic biomarker and therapeutic target for OS patients. SDC2 methylation as a blood-based DNA test for early detection of colorectal cancer (CRC). Synde...
TMPY-00497	ZG16 Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	Zymogen granule protein 16 (ZG16) is one of the most significantly down-regulated genes in colorectal cancer (CRC) tissues. Proteomic analyses of mucus have identified the lectin-like protein ZG16 as an abundant mucus co...
TMPK-00898	EphB3 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Although EphB3 expression is down-regulated in colorectal cancer (CRC) cells compared with normal intestinal epithelial cells.EphB3 is down-regulated in CRC compared to normal mucosa. Hypermethylation of CpG island is co...
TMPJ-01155	PDCD4 Protein, Human, Recombinant (His)	Human	E. coli
	Programmed Cell Death Protein 4 (PDCD4) is a member of the PDCD4 family. PDCD4 and EIF4A1 form a heterotrimer. One molecule of PDCD4 binds two molecules of EIF4A1. PDCD4 takes part in apoptosis via inhibiting translation...
TMPK-01323	CEACAM1 Protein, Canine, Recombinant (His)	Canine	HEK293 Cells
	Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM-1) is the major antigen of the CD66 cluster of granulocyte differentiation antigens. The present study aimed to assess the biological function of CEACAM-1...
TMPK-00869	CEACAM1 Protein, Mouse, Recombinant (aa 35-428, His)	Mouse	HEK293 Cells
	Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM-1) is the major antigen of the CD66 cluster of granulocyte differentiation antigens. The present study aimed to assess the biological function of CEACAM-1...
TMPY-03859	DHRS9 Protein, Human, Recombinant (His)	Human	E. coli
	Dehydrogenase/reductase (SDR family) member 9 (DHRS9) is aberrantly expressed in colorectal cancer (CRC), the decreased expression of DHRS9 correlates with tumor progression and may serve as a potential prognostic bioma...
TMPJ-00796	Serpin E2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Serpin E2 is a secreted protein that belongs to the serpin family. Serpin E2 is a serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Serpin E2 expression is weak or absent in all normal panc...
TMPK-01306	CDH3 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	Placental-Cadherin (CDH3), a cell adhesion molecule, is associated with the function of cells to bind with other cells and the extracellular matrix (ECM). CDH3 is highly expressed in many malignancies, and has been prove...
TMPK-00800	CDH3 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Placental-Cadherin (CDH3), a cell adhesion molecule, is associated with the function of cells to bind with other cells and the extracellular matrix (ECM). CDH3 is highly expressed in many malignancies, and has been prove...
TMPY-02046	PFDN1 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	PFDN1 expression positively correlated with tumor size and tumor invasion. The inhibitory effect of PFDN1 on tumor cell growth and motility was partially due to G2/M cell cycle blockage and cytoskeletal deficiency. PFDN1...
TMPY-03989	PFDN1 Protein, Human, Recombinant (His)	Human	E. coli
	PFDN1 expression positively correlated with tumor size and tumor invasion. The inhibitory effect of PFDN1 on tumor cell growth and motility was partially due to G2/M cell cycle blockage and cytoskeletal deficiency. PFDN1...
TMPK-00753	LY6G6D Protein, Human, Recombinant (His)	Human	HEK293 Cells
	LY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager.LY6G6D was identified as a selectively expressed CRC antigen that can be utiliz...
TMPK-00851	CDH3 Protein, Human, Recombinant (aa 108-654, His)	Human	HEK293 Cells
	Placental-Cadherin (CDH3), a cell adhesion molecule, is associated with the function of cells to bind with other cells and the extracellular matrix (ECM). CDH3 is highly expressed in many malignancies, and has been prove...
TMPK-01332	LY6G6D Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	LY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager.LY6G6D was identified as a selectively expressed CRC antigen that can be utiliz...
TMPY-00150	IGF2/IGF-II Protein, Human, Recombinant	Human	P. pastoris (Yeast)
	Insulin-like growth factor 2 (IGF-2/IGF-II) is a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele,...
TMPK-00752	LY6G6D Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	LY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager.LY6G6D was identified as a selectively expressed CRC antigen that can be utiliz...
TMPY-03329	DPEP1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Dehydropeptidase-I, also known as DPEP1, is a kidney membrane enzyme. Its expression in normal colonic mucosa is very low, but it is highly expressed in colorectal adenoma and cancer specimens and is negatively correl...
TMPK-00754	LY6G6D Protein, Human, Recombinant (His & Strep-II)	Human	HEK293 Cells
	LY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager.LY6G6D was identified as a selectively expressed CRC antigen that can be utiliz...
TMPY-02249	FABP6 Protein, Human, Recombinant	Human	E. coli
	Gastrotropin, also known as Fatty acid-binding protein 6, Ileal lipid-binding protein, ILBP, Intestinal 15 kDa protein, Intestinal bile acid-binding protein, I-BABP and FABP6, is a cytoplasm protein which belongs to t...
TMPJ-01083	Serpin E2 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Serpin E2 is a member of the Serpin superfamily. It is differentially expressed during neuronal differentiation and is able to transform human embryonic kidney cells into neuronlike cells. Its over-expression in mice lea...
TMPY-04267	MSH2 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	MSH2 is a key DNA mismatch repair protein, which plays an important role in genomic stability. In addition to its DNA repair function, MSH2 serves as a sensor for DNA base analogs-provoked DNA replication errors and bind...
TMPY-00924	SMAC Protein, Human, Recombinant (His)	Human	E. coli
	Apoptosis is an essential processes required for normal development and homeostasis of all metazoan organisms. Second Mitochondria-Derived Activator of Caspases (Smac) or Direct IAP Binding Protein with low isoelectric p...
TMPY-02100	TEM7 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Plexin domain-containing protein 1, also known as tumor endothelial marker 3, tumor endothelial marker 7 and PLXDC1 and TEM3, is a secreted, cytoplasm and single-pass type I membrane protein that belongs to the plexin fa...
TMPY-01249	Cathepsin V Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Cathepsin V (CTSV), also known as Cathepsin L2, CTSL2, and CATL2, is a member of the peptidase C1 family. It is predominantly expressed in the thymus and testis. Cathepsin V is also expressed in corneal epithelium, and t...
TMPY-01268	SMYD3 Protein, Human, Recombinant (GST)	Human	Baculovirus Insect Cells
	SET and MYND domain-containing protein 3, also known as Zinc finger MYND domain-containing protein 1, SMYD3, and ZMYND, is a member of the histone-lysine methyltransferase family. SMYD3 contains one MYND-type zinc finger...

RNF43 Protein, Human, Recombinant (His)

TMPY-04153

Species: Human

Expression System: HEK293 Cells

GALNT7 Protein, Human, Recombinant (His)

TMPY-00365

Species: Human

Expression System: HEK293 Cells

IGSF11 Protein, Human, Recombinant (His)

TMPY-02292

Species: Human

Expression System: HEK293 Cells

PPAR gamma/PPARG Protein, Human, Recombinant (His & GST)

TMPY-02575

Species: Human

Expression System: Baculovirus Insect Cells

JUN Protein, Human, Recombinant (His)

TMPH-02218

Species: Human

Expression System: Baculovirus Insect Cells

JUN Protein, Human, Recombinant (His & Myc)

TMPH-02219

Species: Human

Expression System: E. coli

Neogenin Protein, Human, Recombinant (hFc)

TMPK-01131

Species: Human

Expression System: HEK293 Cells

RNF43 Protein, Human, Recombinant (hFc)

TMPY-04149

Species: Human

Expression System: HEK293 Cells

TXNDC17 Protein, Human, Recombinant

TMPY-02572

Species: Human

Expression System: E. coli

Syndecan-2 Protein, Human, Recombinant (His)

TMPY-04249

Species: Human

Expression System: HEK293 Cells

Syndecan-2 Protein, Mouse, Recombinant (His)

TMPY-05168

Species: Mouse

Expression System: HEK293 Cells

ZG16 Protein, Human, Recombinant (mFc)

TMPY-00497

Species: Human

Expression System: HEK293 Cells

EphB3 Protein, Human, Recombinant (His)

TMPK-00898

Species: Human

Expression System: HEK293 Cells

PDCD4 Protein, Human, Recombinant (His)

TMPJ-01155

Species: Human

Expression System: E. coli

CEACAM1 Protein, Canine, Recombinant (His)

TMPK-01323

Species: Canine

Expression System: HEK293 Cells

CEACAM1 Protein, Mouse, Recombinant (aa 35-428, His)

TMPK-00869

Species: Mouse

Expression System: HEK293 Cells

DHRS9 Protein, Human, Recombinant (His)

TMPY-03859

Species: Human

Expression System: E. coli

Serpin E2 Protein, Human, Recombinant (His)

TMPJ-00796

Species: Human

Expression System: HEK293 Cells

CDH3 Protein, Cynomolgus, Recombinant (His)

TMPK-01306

Species: Cynomolgus

Expression System: HEK293 Cells

CDH3 Protein, Mouse, Recombinant (His)

TMPK-00800

Species: Mouse

Expression System: HEK293 Cells

PFDN1 Protein, Mouse, Recombinant (His)

TMPY-02046

Species: Mouse

Expression System: E. coli

PFDN1 Protein, Human, Recombinant (His)

TMPY-03989

Species: Human

Expression System: E. coli

LY6G6D Protein, Human, Recombinant (His)

TMPK-00753

Species: Human

Expression System: HEK293 Cells

CDH3 Protein, Human, Recombinant (aa 108-654, His)

TMPK-00851

Species: Human

Expression System: HEK293 Cells

LY6G6D Protein, Cynomolgus, Recombinant (His)

TMPK-01332

Species: Cynomolgus

Expression System: HEK293 Cells

IGF2/IGF-II Protein, Human, Recombinant

TMPY-00150

Species: Human

Expression System: P. pastoris (Yeast)

LY6G6D Protein, Human, Recombinant (hFc)

TMPK-00752

Species: Human

Expression System: HEK293 Cells

DPEP1 Protein, Human, Recombinant (His)

TMPY-03329

Species: Human

Expression System: HEK293 Cells

LY6G6D Protein, Human, Recombinant (His & Strep-II)

TMPK-00754

Species: Human

Expression System: HEK293 Cells

FABP6 Protein, Human, Recombinant

TMPY-02249

Species: Human

Expression System: E. coli

Serpin E2 Protein, Mouse, Recombinant (His)

TMPJ-01083

Species: Mouse

Expression System: HEK293 Cells

MSH2 Protein, Human, Recombinant (His & GST)

TMPY-04267

Species: Human

Expression System: Baculovirus Insect Cells

SMAC Protein, Human, Recombinant (His)

TMPY-00924

Species: Human

Expression System: E. coli

TEM7 Protein, Human, Recombinant (His)

TMPY-02100

Species: Human

Expression System: HEK293 Cells

Cathepsin V Protein, Human, Recombinant (His)

TMPY-01249

Species: Human

Expression System: HEK293 Cells

SMYD3 Protein, Human, Recombinant (GST)

TMPY-01268

Species: Human

Expression System: Baculovirus Insect Cells

カタログ番号	製品名
L2194	Anti-Colorectal Cancer Compound Library	1545 compounds
	1545 compounds associated with colorectal cancer that can be used for high-throughput and high-content screening.
L6740	Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library	382 compounds
	A collection of 382 TCM monomers with anti-colorectal activity. An effective tool for drug development and pharmacological studies.
L2192	Anti-Pancreatic Cancer Compound Library	2238 compounds
	A unique collection of 2238 pancreatic cancer related compounds can be used in HTS and HCS;
L4300	Wnt/Hedgehog/Notch Compound Library	237 compounds
	A unique collection of 237 Wnt/Hedgehog/Notch signaling targeted compounds for high throughput and high content screening;

ライブラリー

Anti-Colorectal Cancer Compound Library

L2194

Compounds: 1545

Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library

L6740

Compounds: 382

Anti-Pancreatic Cancer Compound Library

L2192

Compounds: 2238

Wnt/Hedgehog/Notch Compound Library

L4300

Compounds: 237